ASCL1 IS ACTIVATED DOWNSTREAM OF THE ROR2/CREB SIGNALING PATHWAY TO SUPPORT LINEAGE PLASTICITY IN PROSTATE CANCER

ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer

Summary: Lineage plasticity is a form of therapy-induced drug Walking Stick resistance.In prostate cancer, androgen receptor (AR) pathway inhibitors potentially lead to the accretion of tumor relapse with loss of AR signaling and a shift from a luminal state to an alternate program.However, the molecular and signaling mechanisms orchestrating the d

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Towards a Taxonomy for In-Vehicle Interactions Using Wearable Smart Textiles: Insights from a User-Elicitation Study

Textiles are a vital and indispensable part of our clothing that we use daily.They are very flexible, often lightweight, and have a variety of application uses.Today, with the rapid developments in small and flexible sensing materials, textiles can be enhanced and used as input devices for interactive systems.Clothing-based wearable interfaces are

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Texture analysis using proton density and T2 relaxation in patients with histological usual interstitial pneumonia (UIP) or nonspecific interstitial pneumonia (NSIP).

The purpose of our study was to assess proton density (PD) and T2 relaxation time of usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) and to evaluate their utility in differentiating the two patterns.Furthermore, we aim to investigate whether these two parameters could help differentiate active-inflammatory Waterproo

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A Smart Grid Framework for Optimally Integrating Supply-Side, Demand-Side and Transmission Line Management Systems

A coordinated centralized energy management system (ConCEMS) is presented in this paper that seeks to integrate for optimal grid operation—the supply side energy management system (SSEMS), home energy management system (HEMS) and transmission line management system (TLMS).ConCEMS in ensuring the optimal operation of an IEEE 30-bus electricity

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Deciphering the effects of genotype and climatic factors on the performance, active ingredients and rhizosphere soil properties of Salvia miltiorrhiza

IntroductionSalvia miltiorrhiza Bunge is an important medicinal herb, which is widely cultivated in most parts of China.It has attracted considerable attention because of its pharmacological properties and potential health benefits.MethodsWe MAGNESIUM CTRATE used a field experiment to determine the effects of different genotypes and climatic factor

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