ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
Summary: Lineage plasticity is a form of therapy-induced drug Walking Stick resistance.In prostate cancer, androgen receptor (AR) pathway inhibitors potentially lead to the accretion of tumor relapse with loss of AR signaling and a shift from a luminal state to an alternate program.However, the molecular and signaling mechanisms orchestrating the d